THERAPEUTIC ANTIBODY-LIKE IMMUNOCONJUGATES AGAINST TISSUE FACTOR WITH THE POTENTIAL TO TREAT ANGIOGENESIS-DEPENDENT AS WELL AS MACROPHAGE-ASSOCIATED HUMAN DISEASES

Accumulating evidence suggests that tissue factor (TF) is selectively expressed in pathological angiogenesis-dependent as well as macrophage-associated human diseases.Pathological angiogenesis, the formation of neovasculature, is involved in many clinically significant human diseases, notably cancer, age-related macular degeneration (AMD), endometr

The USP Apparatus 1 (basket apparatus) is commonly used to evaluate the dissolution performance of oral solid dosage forms.The hydrodynamics generated by Generators the basket contributes, in general, to the dissolution rate and hence the dissolution results.Here, the hydrodynamics of Apparatus 1 was quantified in a vessel filled with 900-mL de-ion